House is recruited by the CIA to help diagnose a deathly ill agent. The agent’s medical case is spearheaded by Dr. Samira Terzi, who offers very little information on the agent’s history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his patient’s life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race.
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Foreman returns to the hospital and is assigned to oversee House’s team candidates. A man is mugged and suffers from a respiratory arrest. He has no memories of who he is, but instead reads the personality of the most dominant person in the room, applying it to himself to create a temporary identity. His accuracy of being a judge of character intrigues House, who manipulates the man to judge others and ultimately judges whether House is more dominant than Cuddy.
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While having a seizure, a funeral home cosmetician hallucinates that she’s being violently raped by one of the corpses she’s working on. Later in the hospital, she acts as though her dead mother is in the room with her. Meanwhile, Cameron offers advice to one of the seven candidates for House’s team; Foreman has lunch with Cuddy.
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The final 10 fellowship candidates compete ferociously when House splits them into two teams by gender. They are assigned to diagnose and treat a wheelchair-bound man with spinal muscular atrophy who is slowly suffocating. As the two teams try to one-up each other, complications arise. Meanwhile, Foreman runs his own team of fellows in his new job at another hospital, and resorts to using a very “House-like” treatment to help a patient.
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House is approached by a fighter pilot named Greta, a candidate for NASA’s astronaut training program. Greta suffers from a neurological disorder in which she is converting sounds to visual images. Knowing that NASA would reject any possibility of her becoming an astronaut if they knew of her problem, Greta begs House to treat her in secret. Meanwhile, House is ruffled when he thinks he sees Cameron, Chase and Foreman in the hospital hallways.
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When an office building collapses, House has to work fast to diagnose a young woman, Megan, who survived the disaster. Due to her injuries, Megan’s only form of communication is blinking. House, without a team since Foreman and Cameron quit and he fired Chase, talks through his ideas with a janitor at the hospital. As House persists in diagnosing Megan by himself, he realizes that the case is not what it appears, and that solitude may not be the answer.
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